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1

Development of Spray-Freeze-Dried Powders for Inhalation with High Inhalation Performance and Antihygroscopic Property

Otake, Hiroko, Okuda, Tomoyuki, Okamoto, Hirokazu

Année:

2016

Langue:

english

Fichier:

PDF, 2.42 MB

english, 2016

2

Development of spray-freeze-dried siRNA/PEI powder for inhalation with high aerosol performance and strong pulmonary gene silencing activity

Okuda, Tomoyuki, Morishita, Masaki, Mizutani, Kimiyasu, Shibayama, Ayumi, Okazaki, Maki, Okamoto, Hirokazu

Journal:

Journal of Controlled Release

Année:

2018

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2018

3

Naked pDNA inhalation powder composed of hyaluronic acid exhibits high gene expression in the lungs

Ito, Takaaki, Okuda, Tomoyuki, Takashima, Yoshimasa, Okamoto, Hirokazu

Journal:

Molecular Pharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2018

4

ChemInform Abstract: Orally Active Cephalosporins. Part 4. Synthesis, Structure—Activity Relationships and Oral Absorption of Novel 3-(4-Pyrazolylmethylthio)cephalosporins with Various C-7 Side Chains.

Hirofumi Yamamoto, Yoshiteru Eikyu, Shinya Okuda, Kohji Kawabata, Hisashi Takasugi, Hirokazu Tanada, Satoru Matsumoto, Yoshimi Matsumoto, Shuichi Tawara

Journal:

Année:

2002

Fichier:

PDF, 26 KB

2002

5

Low-resistive and transparent AZO films prepared by PLD in magnetic field

Hideaki Agura, Hirokazu Okinaka, Shigeyasu Hoki, Takanori Aoki, Akio Suzuki, Tatsuhiko Matsushita, Masahiro Okuda

Journal:

Electrical Engineering in Japan

Année:

2005

Langue:

english

Fichier:

PDF, 4.61 MB

english, 2005

6

Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent β-N-acetylglucosaminidase inhibitor

Hirokazu Usuki, Miho Toyo-oka, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 373 KB

english, 2009

7

Orally Active Cephalosporins. Part 4: Synthesis, Structure–Activity Relationships and Oral Absorption of Novel 3-(4-Pyrazolylmethylthio)cephalosporins with Various C-7 Side Chains

Hirofumi Yamamoto, Yoshiteru Eikyu, Shinya Okuda, Kohji Kawabata, Hisashi Takasugi, Hirokazu Tanaka, Satoru Matsumoto, Yoshimi Matsumoto, Shuichi Tawara

Journal:

Bioorganic & Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 227 KB

english, 2002

8

Expression of hepatoma-derived growth factor in hepatocarcinogenesis

KENYA YOSHIDA, HIDEJI NAKAMURA, YORIHIDE OKUDA, HIRAYUKI ENOMOTO, YOSHIHIKO KISHIMA, HIROKAZU UYAMA, HIROAKI ITO, TSUTOMU HIRASAWA, SHUICHIRO INAGAKI, ICHIRO KAWASE

Journal:

Journal of Gastroenterology and Hepatology

Année:

2003

Langue:

english

Fichier:

PDF, 604 KB

english, 2003

9

Inhalation Performance of Physically Mixed Dry Powders Evaluated with a Simple Simulator for Human Inspiratory Flow Patterns

Daiki Hira, Tomoyuki Okuda, Daisuke Kito, Kazunori Ishizeki, Toyoko Okada, Hirokazu Okamoto

Journal:

Pharmaceutical Research

Année:

2010

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2010

10

Embryotoxic effects of ethylene glycol monomethyl ether in mice

Kasuke Nagano, Eiki Nakayama, Hisao Oobayashi, Tsutomu Yamada, Hidemi Adachi, Tomoshi Nishizawa, Harumi Ozawa, Momoko Nakaichi, Hirokazu Okuda, Kyoko Minami, Kazunori Yamazaki

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 410 KB

english, 1981

11

Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats

Hirokazu Okuda, Tetsuji Nagao

Journal:

Congenital Anomalies

Année:

2006

Langue:

english

Fichier:

PDF, 100 KB

english, 2006

12

Differences in spontaneous fetal abnormalities among three outbred stocks of Wistar Hannover rats in Japan

Tetsuya Takeuchi, Hirokazu Okuda, Yoko Kasahara, Sugako Ushigome, Ikue Aihara, Shoji Fukushima

Journal:

Congenital Anomalies

Année:

2011

Langue:

english

Fichier:

PDF, 108 KB

english, 2011

13

Pleiotropic Functions of PACAP in the CNS : Neuroprotection and Neurodevelopment

SEIJI SHIODA, HIROKAZU OHTAKI, TOMOYA NAKAMACHI, KENJI DOHI, JUN WATANABE, SHIGEO NAKAJO, SATORU ARATA, SHINJI KITAMURA, HIROMI OKUDA, FUMIKO TAKENOYA, YOSHITAKA KITAMURA

Journal:

Annals of the New York Academy of Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 96 KB

english, 2006

14

Hepatoma-Derived Growth Factor Is a Novel Prognostic Factor for Hepatocellular Carcinoma

Kenya Yoshida, Yasuhiko Tomita, Yorihide Okuda, Shinji Yamamoto, Hirayuki Enomoto, Hirokazu Uyama, Hiroaki Ito, Yoshihiko Hoshida, Katsuyuki Aozasa, Hiroaki Nagano, Masato Sakon, Ichiro Kawase, Morito

Journal:

Annals of Surgical Oncology

Année:

2006

Langue:

english

Fichier:

PDF, 663 KB

english, 2006

15

Optimized pulmonary gene transfection in mice by spray–freeze dried powder inhalation

Kohta Mohri, Tomoyuki Okuda, Asami Mori, Kazumi Danjo, Hirokazu Okamoto

Journal:

Journal of Controlled Release

Année:

2010

Langue:

english

Fichier:

PDF, 425 KB

english, 2010

16

Developmental effects of inhalation exposure to 2-bromopropane in rats

Tetsuya Takeuchi, Hirokazu Okuda, Heihachiro Arito, Kasuke Nagano, Seigo Yamamoto, Taijiro Matsushima

Journal:

Reproductive Toxicology

Année:

2004

Langue:

english

Fichier:

PDF, 83 KB

english, 2004

17

Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4′-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats

Kanji Yamasaki, Hirokazu Okuda

Journal:

Toxicology Letters

Année:

2012

Langue:

english

Fichier:

PDF, 274 KB

english, 2012

18

Development of Oxide Dispersion Strengthened Ferritic Steels for FBR Core Application, (I)

UKAI, Shigeharu, NISHIDA, Toshio, OKADA, Hirokazu, OKUDA, Takanari, FUJIWARA, Masayuki, ASABE, Kazutaka

Journal:

Journal of Nuclear Science and Technology

Année:

1997

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1997

19

Triple therapy of initial high-dose interferon with ribavirin and amantadine for patients with chronic hepatitis C

Hirokazu Uyama, Hideji Nakamura, Eijiro Hayashi, Hiroyuki Ogawa, Hirayuki Enomoto, Kenya Yoshida, Yorihide Okuda, Mitsunari Yamamoto, Toshikazu Hada, Norio Hayashi

Journal:

Hepatology Research

Année:

2007

Langue:

english

Fichier:

PDF, 150 KB

english, 2007

20

Large out-of-plane spin polarization in a spin-splitting one-dimensional metallic surface state on Si(557)-Au

Okuda, Taichi, Miyamaoto, Koji, Takeichi, Yasuo, Miyahara, Hirokazu, Ogawa, Manami, Harasawa, Ayumi, Kimura, Akio, Matsuda, Iwao, Kakizaki, Akito, Shishidou, Tatsuya, Oguchi, Tamio

Journal:

Physical Review B

Année:

2010

Langue:

english

Fichier:

PDF, 985 KB

english, 2010

21

Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor

Yorihide Okuda, Hideji Nakamura, Kenya Yoshida, Hirayuki Enomoto, Hirokazu Uyama, Tomonori Hirotani, Masanobu Funamoto, Hiroaki Ito, Allen D Everett, Toshikazu Hada, Ichiro Kawase

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 3.01 MB

english, 2003

22

OECD validation of the Hershberger assay in Japan: Phase 3. Blind study using coded chemicals

Kanji Yamasaki, Ryo Ohta, Hirokazu Okuda

Journal:

Toxicology Letters

Année:

2006

Langue:

english

Fichier:

PDF, 388 KB

english, 2006

23

Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p′-DDE in Sprague–Dawley rats

Kanji Yamasaki, Hirokazu Okuda, Tetsuya Takeuchi, Yasushi Minobe

Journal:

Toxicology Letters

Année:

2009

Langue:

english

Fichier:

PDF, 236 KB

english, 2009

24

Efficient spin resolved spectroscopy observation machine at Hiroshima Synchrotron Radiation Center

Okuda, Taichi, Miyamaoto, Koji, Miyahara, Hirokazu, Kuroda, Kenta, Kimura, Akio, Namatame, Hirofumi, Taniguchi, Masaki

Journal:

Review of Scientific Instruments

Année:

2011

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2011

25

Experimental Studies on Toxicity of Ethylene Glycol Alkyl Ethers in Japan

Kasuke Nagano, Eiki Nakayama, Hisao Oobayashi, Tomoshi Nishizawa, Hirokazu Okuda and Kazunori Yamazaki

Journal:

Environmental Health Perspectives

Année:

1984

Langue:

english

Fichier:

PDF, 4.03 MB

english, 1984

26

OECD Validation of the Hershberger Assay in Japan: Phase 2 Dose Response of Methyltestosterone, Vinclozolin, and p,p'-DDE

Kanji Yamasaki, Masakuni Sawaki, Ryo Ohta, Hirokazu Okuda, Seiichi Katayama, Tomoya Yamada, Takafumi Ohta, Tadashi Kosaka and William Owens

Journal:

Environmental Health Perspectives

Année:

2003

Langue:

english

Fichier:

PDF, 4.08 MB

english, 2003

27

Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore

Nomura, Wataru, Ohashi, Nami, Okuda, Yoshiaki, Narumi, Tetsuo, Ikura, Teikichi, Ito, Nobutoshi, Tamamura, Hirokazu

Journal:

Bioconjugate Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2011

28

PEG conjugation of a near-infrared fluorescent probe for noninvasive dual imaging of lung deposition and gene expression by pulmonary gene delivery

Okuda, Tomoyuki, Kobayashi, Yuko, Yanamoto, Shinya, Okamoto, Hirokazu

Journal:

Journal of Drug Targeting

Année:

2012

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2012

29

Preparation of C 60 Thin Films and Cs-Rb Doping

Okuda, Nobuyuki, Kugai, Hirokazu, Okura, Kengo, Ueba, Yoshinobu, Tada, Koji

Journal:

Fullerene Science and Technology

Année:

1993

Langue:

english

Fichier:

PDF, 338 KB

english, 1993

30

Expression of Angiotensin II Receptor-like 1 in the Placentas of Pregnancy-induced Hypertension

Furuya, Mitsuko, Okuda, Mika, Usui, Hirokazu, Takenouchi, Toshinao, Kami, Daisuke, Nozawa, Akinori, Shozu, Makio, Umezawa, Akihiro, Takahashi, Tsuneo, Aoki, Ichiro

Journal:

International Journal of Gynecological Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 467 KB

english, 2012

31

Explosive Crystallization in Eutectic Materials of Phase Change Optical Memory

Okuda, Masahiro, Inaba, Hirokazu, Usuda, Shouji

Journal:

MRS Proceedings

Année:

2003

Langue:

english

Fichier:

PDF, 837 KB

english, 2003

32

Two-week Toxicity of Multi-walled Carbon Nanotubes by Whole-body Inhalation Exposure in Rats

UMEDA, Yumi, KASAI, Tatsuya, SAITO, Misae, KONDO, Hitomi, TOYA, Tadao, AISO, Shigetoshi, OKUDA, Hirokazu, NISHIZAWA, Tomoshi, FUKUSHIMA, Shoji

Journal:

Journal of Toxicologic Pathology

Année:

2013

Langue:

english

Fichier:

PDF, 3.34 MB

english, 2013

33

Novel method using hybrid markers: development of an approach for pulmonary measurement of multi-walled carbon nanotubes

Ohnishi, Makoto, Yajima, Hirofumi, Kasai, Tatsuya, Umeda, Yumi, Yamamoto, Masahiro, Yamamoto, Seigo, Okuda, Hirokazu, Suzuki, Masaaki, Nishizawa, Tomoshi, Fukushima, Shoji

Journal:

Journal of Occupational Medicine and Toxicology

Année:

2013

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2013

34

Discussion on Scanning Tunneling Microscopy Images with Resonant Tunneling Model

Inaba, Hirokazu, Yagi, Yoshikazu, Okuda, Masahiro

Journal:

Japanese Journal of Applied Physics

Année:

1995

Fichier:

PDF, 920 KB

1995

35

Dynamics of Resonant Tunneling in Double-Barrier Structures with Trapezoidal Potential Profile

Inaba, Hirokazu, Nakagawa, Jun, Kurosawa, Kou, Okuda, Masahiro

Journal:

Japanese Journal of Applied Physics

Année:

1991

Fichier:

PDF, 437 KB

1991

36

Clinical outcome in patients with small intestinal non-Hodgkin lymphoma

Kako, Shinichi, Oshima, Kumi, Sato, Miki, Terasako, Kiriko, Okuda, Shinya, Nakasone, Hideki, Yamazaki, Rie, Tanaka, Yukie, Tanihara, Aki, Kawamura, Yutaka, Kiyosaki, Hirokazu, Higuchi, Takakazu, Nishi

Journal:

Leukemia and Lymphoma

Année:

2009

Langue:

english

Fichier:

PDF, 481 KB

english, 2009

37

SPIE Proceedings [SPIE Optical Storage (ISOS 2002) - Wuhan, China (Sunday 22 September 2002)] Sixth International Symposium on Optical Storage (ISOS 2002) - Crystallization in eutectic materials of phase-change optical memory

Okuda, Masahiro, Inaba, Hirokazu, Usuda, Shouji, Gan, Fuxi, Li, Zuoyi

Année:

2003

Langue:

english

Fichier:

PDF, 214 KB

english, 2003

38

Sigma-1 receptor is a molecular target for novel neuroprotectant T-817MA

Yano, Takeaki, Tanabe, Hirokazu, Kobayashi, Kaoru, Kobayashi, Hayato, Nabetani, Akira, Sakai, Yoshiyuki, Okuda, Tomohiro, Nakagawa, Masaya, Nakamura, Takaaki

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 191 KB

english, 2015

39

Drug Permeation Characterization of Inhaled Dry Powder Formulations in Air-Liquid Interfaced Cell Layer Using an Improved, Simple Apparatus for Dispersion

Asai, Ayumu, Okuda, Tomoyuki, Sonoda, Erina, Yamauchi, Tomoyo, Kato, Saki, Okamoto, Hirokazu

Journal:

Pharmaceutical Research

Année:

2016

Langue:

english

Fichier:

PDF, 5.77 MB

english, 2016

40

SPIE Proceedings [SPIE Seventh International Symposium on Optical Storage (ISOS 2005) - Zhanjiang, China (Saturday 2 April 2005)] Seventh International Symposium on Optical Storage - Dynamic phase transition of explosive structure in eutectic recording layer using spreadsheet program

Usuda, Shouji, Gan, Fuxi, Hou, Lisong, Inoue, Shoshi, Itou, Satoshi, Inaba, Hirokazu, Jiang, Fusong, Okuda, Masahiro, Chen, Yu Hung

Année:

2005

Langue:

english

Fichier:

PDF, 919 KB

english, 2005

41

SPIE Proceedings [SPIE Optical Storage (ISOS 2002) - Wuhan, China (Sunday 22 September 2002)] Sixth International Symposium on Optical Storage (ISOS 2002) - Computer simulation with spreadsheet to analyze crystalline structure in eutectic recording layer by fractal theory

Usuda, Shouji, Okuda, Masahiro, Inaba, Hirokazu, Gan, Fuxi, Li, Zuoyi

Année:

2003

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2003

42

SPIE Proceedings [SPIE Seventh International Symposium on Optical Storage (ISOS 2005) - Zhanjiang, China (Saturday 2 April 2005)] Seventh International Symposium on Optical Storage - Photo-and current-induced crystallization of optical and electrical memory in phase change materials

Okuda, Masahiro, Gan, Fuxi, Hou, Lisong, Inaba, Hirokazu, Usuda, Shouji

Année:

2005

Langue:

english

Fichier:

PDF, 295 KB

english, 2005

43

An Analysis of the Fluttering of a Membrane Suspended in Air Flow

Minami, Hirokazu, Okuda, Yasuo, Kawamura, Sumio

Journal:

International Journal of Clothing Science and Technology

Année:

1994

Langue:

english

Fichier:

PDF, 154 KB

english, 1994

44

Effects of Liver-Supplemented Food on the Development of Embryos in Mice

Akase, Tomoko, Yamashina, Shohei, Akase, Tomohide, Onodera, Satoshi, Okuda, Hirokazu, Tashiro, Shin-ichi

Journal:

Biological & Pharmaceutical Bulletin

Année:

2003

Langue:

english

Fichier:

PDF, 91 KB

english, 2003

45

Improving the Stability of Short Hairpin RNA against Fetal Bovine Serum Using the Third Double-Stranded RNA-Binding Domain from Staufen Protein

Kawaguchi, Yasuhisa, Danjo, Kazumi, Okuda, Tomoyuki, Okamoto, Hirokazu

Journal:

Biological & Pharmaceutical Bulletin

Année:

2009

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2009

46

Gene Silencing in a Mouse Lung Metastasis Model by an Inhalable Dry Small Interfering RNA Powder Prepared Using the Supercritical Carbon Dioxide Technique

Okuda, Tomoyuki, Kito, Daisuke, Oiwa, Ai, Fukushima, Michiko, Hira, Daiki, Okamoto, Hirokazu

Journal:

Biological & Pharmaceutical Bulletin

Année:

2013

Langue:

english

Fichier:

PDF, 3.41 MB

english, 2013

47

Safety Evaluation of Dry Powder Formulations by Direct Dispersion onto Air–Liquid Interface Cultured Cell Layer

Asai, Ayumu, Okuda, Tomoyuki, Yamauchi, Tomoyo, Sugiura, Yuka, Okamoto, Hirokazu

Année:

2016

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2016

48

Development of New Formulation Dry Powder for Pulmonary Delivery Using Amino Acids to Improve Stability

Suzuki, Yumiko, Okuda, Tomoyuki, Okamoto, Hirokazu

Année:

2016

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2016

49

Influence of Peak Inspiratory Flow Rates and Pressure Drops on Inhalation Performance of Dry Powder Inhalers

Hira, Daiki, Okuda, Tomoyuki, Ichihashi, Mika, Mizutani, Ayano, Ishizeki, Kazunori, Okada, Toyoko, Okamoto, Hirokazu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Année:

2012

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2012

50

Development of Dry Salbutamol Sulfate Powder with High Inhalation Performance Independent of Inhalation Patterns

Hira, Daiki, Okuda, Tomoyuki, Ichihashi, Mika, Kojima, Haruyoshi, Okamoto, Hirokazu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Année:

2012

Langue:

english

Fichier:

PDF, 4.97 MB

english, 2012